GHK-CU

GHK-Cu (Copper Peptide, Copper Tripeptide-1) is the copper(II) complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys · Cu²⁺), CAS 89030-95-5, MW ~403.9. Supplied as a ≥99% HPLC-tested lyophilized powder — with a lot-specific third-party COA available before purchase — for in-vitro and laboratory research applications only. Research Use Only — not for human or veterinary use.

Price range: $45.00 through $65.00

Quantity	Price	Discount
5-10	$43.20	4%
11-15	$41.40	8%
16-20	$39.60	12%
21+	$37.80	16%

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Description

GHK-Cu is the copper(II) complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys), in which the peptide coordinates a single copper(II) ion in a 1:1 stoichiometry to form a characteristic deep cobalt-blue complex. First isolated from human plasma by Pickart in 1973, GHK is a small signal-peptide sequence; the copper-bound form is the compound most often referred to in the literature as “copper peptide” or “copper tripeptide-1.”

This product is supplied as a lyophilized powder in multiple sizes, synthesized and complexed to research grade, and characterized by HPLC (purity) and LC-MS (identity), with a lot-specific third-party Certificate of Analysis available before purchase. It is intended exclusively for in-vitro laboratory research and analytical applications.

In the research literature, GHK-Cu is referenced as a reference copper-peptide complex used as a tool compound in the study of copper coordination chemistry, peptide–metal binding, and gene-expression research in cell-based models.

Additional information

Size	100mg, 50mg
Compound Name	GHK-Cu (Copper Peptide)
Synonyms	Copper tripeptide-1; Prezatide copper; Cu-GHK; GHK-Cu copper peptide; copper peptide
CAS Number (complex)	89030-95-5
CAS Number (free peptide)	49557-75-7
Molecular Formula	C₁₄H₂₄N₆O₄·Cu
Molecular Weight	~403.9 g/mol (copper complex); 340.38 g/mol (free GHK)
Sequence	Glycyl-L-histidyl-L-lysine (Gly-His-Lys / GHK)
Structure	Copper(II) coordination complex of the GHK tripeptide (1:1); deep cobalt-blue
Compound Class	Copper-peptide complex (copper tripeptide)
Purity	≥99% (HPLC) — see lot COA
Identity	Confirmed by LC-MS (per lot COA)
Appearance	Blue lyophilized powder (copper complex)
Solubility	Soluble in water
Available Sizes	50mg or 100mg
Storage (lyophilized)	-20°C, sealed, dark, dry
Storage (reconstituted)	2–8°C short-term; aliquot & freeze -20°C; avoid freeze-thaw
Synthesis	Synthetic (SPPS + copper complexation)
Testing Lab	Freedom Diagnostics
Test Methods	Purity by HPLC; identity by LC-MS
Shipped From	USA
Certificate of Analysis	Lot-specific COA available

GHK-Cu (Copper Peptide) — Frequently Asked Questions

What is GHK-Cu?

GHK-Cu is the copper(II) complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys), also known as copper tripeptide-1. It is supplied as a lyophilized powder for laboratory research use only.

What is the molecular weight and CAS number of GHK-Cu?

The GHK-Cu copper complex has a molecular weight of approximately 403.9 g/mol and CAS number 89030-95-5. The metal-free GHK peptide is 340.38 g/mol (CAS 49557-75-7).

What is the sequence of GHK-Cu?

GHK-Cu is based on the tripeptide sequence glycyl-L-histidyl-L-lysine (Gly-His-Lys), coordinated 1:1 with a copper(II) ion.

Why is GHK-Cu blue?

The deep cobalt-blue color is characteristic of the intact copper(II)–peptide coordination complex and reflects successful copper binding by the GHK sequence.

What purity is this GHK-Cu?

This product is ≥99% pure as verified by HPLC, with identity confirmed by LC-MS. A lot-specific Certificate of Analysis from a third-party laboratory is available.

What sizes are available?

This product is available in multiple vial sizes (e.g., 50mg and 100mg) as a research-grade lyophilized powder.

How should GHK-Cu be stored?

Store lyophilized material sealed at -20°C, protected from light and moisture. After reconstitution, store at 2–8°C short-term or aliquot and freeze at -20°C, avoiding repeated freeze-thaw cycles.

Is a Certificate of Analysis (COA) available?

Yes. Each lot has a Certificate of Analysis from an independent third-party laboratory documenting HPLC purity and LC-MS identity confirmation, tied to the vial lot number.

Do you provide dosing, application, or usage instructions?

No. All products are supplied strictly for laboratory research use only. We do not provide dosing, application, administration, or usage guidance of any kind. Researchers determine experimental parameters according to their own validated protocols and applicable regulations.

Research Context

Provided for scientific background only; this does not describe any product use.

Copper-peptide coordination chemistry — reference complex for studies of Cu²⁺ binding by the GHK sequence (histidine imidazole + N-terminal amine coordination).
Peptide–metal interaction research — tool compound for metal-chelation and copper-transport studies in vitro.
Gene-expression / transcriptomic research — referenced in in-vitro studies of GHK-Cu-associated gene-expression changes in cultured cells.
Analytical / method-development studies — used as a copper-peptide reference standard in HPLC and MS method development.

Handling & Storage

For laboratory research handling only.

Reconstitution. GHK-Cu is water-soluble. Reconstitution solvent should be selected according to your experimental protocol; common research-grade options include HPLC-grade ultrapure water. Validate compatibility with your assay system before use. Add solvent slowly down the vial wall; allow to dissolve fully. The characteristic blue color reflects the intact copper complex.

Storage — lyophilized. Store sealed at -20°C, protected from light and moisture.

Storage — reconstituted. Store at 2–8°C short-term, or aliquot and freeze at -20°C. Avoid repeated freeze-thaw cycles. Determine working concentrations using your own validated laboratory methods.

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