GLP-1SG
GLP-1SG is a synthetic 31-amino-acid peptide characterized in the receptor-pharmacology research literature as a single-receptor agonist at the GLP-1 receptor (GLP-1R) (CAS 910463-68-2, MW ~4113.6). Supplied as a ≥99% HPLC-UV purity lyophilized powder, 10 mg labeled size, with identity confirmed by LC-MS across multiple charge states. Lot-specific Certificate of Analysis from Freedom Diagnostics (USA). Research Use Only — not for human or veterinary use.
Price range: $75.00 through $120.00
| Quantity | Price | Discount |
|---|---|---|
| 5-10 | $72.00 | 4% |
| 11-15 | $69.00 | 8% |
| 16-20 | $66.00 | 12% |
| 21+ | $63.00 | 16% |
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GLP-1SG — the compound is a synthetic 31-amino-acid peptide characterized in the receptor-pharmacology research literature as a single-receptor agonist at the glucagon-like peptide-1 receptor (GLP-1R). It is built on the GLP-1(7-37) peptide backbone and incorporates an α-aminoisobutyric acid (Aib) substitution at position 8, and a lipidated lysine at position 26 carrying a C18 fatty diacid via a γGlu-linked hydrophilic spacer — structural features that contribute to its half-life and pharmacokinetic profile as a research tool compound.
This product is supplied as a white lyophilized powder at 10 mg labeled size, synthesized by solid-phase peptide synthesis (SPPS) and characterized by HPLC with UV detection (purity) and LC-MS (identity, expected convergent observations at charge states [M+5H]⁵⁺, [M+4H]⁴⁺, and [M+3H]³⁺ back-calculating to ~4113.6 Da). Third-party characterization is performed by Freedom Diagnostics (USA). The product is intended exclusively for in-vitro laboratory research and analytical applications.
In the research literature, GLP-1R is referenced as a synthetic GLP-1R agonist used as a tool compound in the study of GLP-1 receptor pharmacology and signaling. Within the True Peptide Labs GLP research family, (GLP-1SG) is the single-receptor member — distinct from the dual-receptor GLP-2TZ (GLP-1R/GIPR) and the triple-receptor GLP-3RT (GLP-1R/GIPR/GCGR) — each characterized as tool compounds in incretin-receptor pharmacology research.
| Size | 10mg, 15mg, 20mg, 30mg |
|---|---|
| Compound Name | GLP-1SG |
| Synonyms / Also Known As | SG; SG peptide; GLP-1 SG |
| CAS Number | 910463-68-2 |
| Molecular Formula | aC₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | ~4113.6 g/mol |
| Peptide Length | 31 amino acids (synthetic) |
| Structure | Synthetic peptide based on the GLP-1(7-37) backbone; α-aminoisobutyric acid (Aib) substitution at position 8 (position 2 in Semaglutide numbering); lipidated Lys at position 26 carrying a C18 fatty diacid via γGlu spacer and hydrophilic linker |
| Receptor Target (identity, literature-referenced) | GLP-1R (single-receptor agonist — as distinct from dual-agonist GLP-2TZand triple-agonist GLP-3RTwithin the GLP research family) |
| Compound Class | Synthetic single-receptor GLP-1R agonist peptide |
| Product Type | Peptide |
| Identity Confirmation | Confirmed by LC-MS (per lot COA) — expected charge-state observations at [M+5H]⁵⁺ ~823.7, [M+4H]⁴⁺ ~1029.4, [M+3H]³⁺ ~1372.5 (calculated from MW 4113.6; confirm actual observed values against your lot COA) |
| Purity | ≥99% (HPLC-UV) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water |
| Storage (lyophilized) | -20°C, sealed, protected from light/moisture |
| Storage (reconstituted) | 2–8°C short-term; aliquot & freeze -20°C; avoid freeze-thaw |
| Synthesis | Solid-phase peptide synthesis (SPPS) |
| Testing Lab | Freedom Diagnostics, USA |
| Principal Chemist (on COA) | Alex Johnson |
| Test Methods | Purity by HPLC with UV detection; identity by LC-MS |
| Shipped From | USA |
| Certificate of Analysis | Lot-specific COA available |
The following describes investigative contexts in which this compound appears in the scientific literature. Provided for scientific background only; this does not describe any product use.
- GPCR pharmacology — used as a reference GLP-1R agonist in in-vitro receptor-binding and cAMP-accumulation assays (CRE-luc, HTRF cAMP) at GLP-1R.
- Receptor selectivity studies — a tool compound for probing GLP-1R selectivity in comparative in-vitro characterization against dual-receptor (GLP-1R/GIPR) and triple-receptor (GLP-1R/GIPR/GCGR) agonist tool compounds within the same class.
- Incretin receptor signaling research — referenced in in-vitro and cellular models of GLP-1R signaling.
- Analytical method development — used as a lipidated-peptide reference with a distinctive multi-charge-state MS profile in HPLC-UV and LC-MS method development.
For laboratory research handling only.
Reconstitution. Reconstitution solvent should be selected according to your experimental protocol and stability requirements. Common research-grade options include HPLC-grade ultrapure water or dilute acetic acid. Validate compatibility with your assay system before use. Add solvent slowly down the vial wall; do not shake vigorously, and allow to dissolve fully before use.
Storage — lyophilized. Store sealed at -20°C, protected from light and moisture.
Storage — reconstituted. Store at 2–8°C short-term, or aliquot and freeze at -20°C for longer-term storage. Avoid repeated freeze-thaw cycles. Determine working concentrations using your own validated laboratory methods.
GLP-1SG (Semaglutide) — Frequently Asked Questions
What is GLP-1SG?
GLP-1SG — also known as Semaglutide or "SG" — is a synthetic 31-amino-acid peptide characterized in the receptor-pharmacology research literature as a single-receptor agonist at the GLP-1 receptor. It is supplied as a lyophilized powder for laboratory research use only.
Is Semaglutide a peptide?
Yes. Semaglutide (GLP-1SG) is a synthetic 31-amino-acid peptide. It is characterized as a single GLP-1 receptor agonist in receptor-pharmacology research.
What is the molecular weight and CAS number of Semaglutide?
GLP-1SG (Semaglutide) has an approximate molecular weight of 4113.6 g/mol and CAS number 910463-68-2. Identity on the lot COA is confirmed by LC-MS across multiple charge states, with expected observations at [M+5H]5+ approximately 823.7, [M+4H]4+ approximately 1029.4, and [M+3H]3+ approximately 1372.5, back-calculating to the expected mass.
What receptor does GLP-1SG target?
In receptor-pharmacology research, GLP-1SG is characterized as a single-receptor agonist at the GLP-1 receptor (GLP-1R). Within the GLP research family carried by True Peptide Labs, GLP-1SG is the single-receptor member — distinct from the dual-receptor GLP-2TZ (Tirzepatide, GLP-1R and GIP receptor) and the triple-receptor GLP-3RT (Retatrutide, GLP-1R, GIP receptor, and glucagon receptor). Each is characterized as a receptor-pharmacology tool compound.
What sizes and purity are available?
This product is available as 10 mg per vial at greater than or equal to 99 percent HPLC-UV purity, with identity confirmed by LC-MS. A lot-specific Certificate of Analysis from Freedom Diagnostics (USA) is available.
How should GLP-1SG be stored?
Store lyophilized material sealed at -20C, protected from light and moisture. After reconstitution, store at 2-8C short-term or aliquot and freeze at -20C, avoiding repeated freeze-thaw cycles.
Is a Certificate of Analysis (COA) available?
Yes. Each lot has a Certificate of Analysis from an independent third-party laboratory (Freedom Diagnostics, USA) documenting HPLC purity and LC-MS identity confirmation, tied to the vial lot number.
Do you provide dosing or usage instructions?
No. All products are supplied strictly for laboratory research use only. We do not provide dosing, administration, or usage guidance of any kind. Researchers determine experimental parameters according to their own validated protocols and applicable regulations.
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