GLP-2TZ

Name: GLP‑2TZ Research Peptide | True Peptide Labs
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GLP-2TZ (LY3298176) is a synthetic 39-amino-acid peptide and dual agonist at the GIP and GLP-1 receptors (CAS 2023788-19-2, MW ~4813.45). Supplied as a ≥99% HPLC-tested lyophilized powder — with a lot-specific third-party COA available before purchase — for in-vitro and laboratory research applications only. Research Use Only — not for human or veterinary use.

Price range: $75.00 through $250.00

Quantity	Price	Discount
5-10	$72.00	4%
11-15	$69.00	8%
16-20	$66.00	12%
21+	$63.00	16%

🧬 99%+ HPLC Purity
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Description

GLP-2TZ (LY3298176) is a synthetic 39-amino-acid peptide that acts as a dual agonist at two receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R). Its primary structure is based on the GIP sequence and incorporates non-coded residues (α-aminoisobutyric acid, Aib) and a C20 fatty-diacid moiety conjugated at the lysine-20 residue via a γ-glutamic-acid linker, contributing to its structural stability profile.

This product is supplied as a lyophilized powder in multiple sizes, synthesized by solid-phase peptide synthesis (SPPS) and characterized by HPLC (purity) and LC-MS (identity), with a lot-specific third-party Certificate of Analysis available before purchase. It is intended exclusively for in-vitro laboratory research and analytical applications.

In the research literature, GLP-2TZ is referenced as a reference dual-receptor agonist used as a tool compound in the study of GIPR and GLP-1R receptor pharmacology and signaling.

Additional information

Size	10mg, 15mg, 30mg, 60mg
Compound Name	GLP-2TZ
Synonyms	Tirz; LY3298176; LY-3298176; GLP-2 TZ; GIP/GLP-1 RA
CAS Number	2023788-19-2
Molecular Formula	C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight	~4813.45 g/mol
Peptide Length	39 amino acids (synthetic)
Structure	GIP-based sequence; C20 fatty-diacid moiety via γ-glutamic-acid linker at Lys20; Aib residues; C-terminal amide
Receptor Targets	GIPR, GLP-1R (dual agonist)
Compound Class	Synthetic dual incretin (GIP/GLP-1) receptor agonist peptide
Purity	≥99% (HPLC) — see lot COA
Identity	Confirmed by LC-MS (per lot COA)
Appearance	White lyophilized powder
Solubility	Soluble in water / aqueous buffer
Available Sizes	0mg, 15mg, 30mg, 60mg
Storage (lyophilized)	-20°C, sealed, dark, dry
Storage (reconstituted)	2–8°C short-term; aliquot & freeze -20°C; avoid freeze-thaw
Synthesis	Solid-phase peptide synthesis (SPPS)
Testing Lab	Freedom Diagnostics
Test Methods	Purity by HPLC; identity by LC-MS
Shipped From	USA
Certificate of Analysis	Lot-specific COA available

FAQ

GLP-2TZ — Frequently Asked Questions

What is GLP-2TZ?

GLP-2TZ (LY3298176) — is a synthetic 39-amino-acid peptide that acts as a dual agonist at the GIP and GLP-1 receptors. It is supplied as a lyophilized powder for laboratory research use only.

Is tirzepatide a peptide?

Yes. (GLP-2TZ) is a synthetic 39-amino-acid peptide, characterized as a dual GIP/GLP-1 receptor agonist in receptor-pharmacology research.

What is the molecular weight and CAS number of GPL-2TZ?

GLP-2TZ has an approximate molecular weight of 4813.45 g/mol and CAS number 2023788-19-2.

What receptors does GLP-2TZ target?

In receptor-pharmacology research, GLP-2TZ is characterized as a dual agonist at the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R).

Is a Certificate of Analysis available, and can I see it before buying?

Yes. A lot-specific Certificate of Analysis from an independent third-party laboratory is available before purchase, documenting HPLC purity and LC-MS identity confirmation tied to the vial lot number.

What sizes and purity are available?

Available in multiple vial sizes at ≥99% HPLC purity, identity confirmed by LC-MS.

How should GLP-2TZ be stored?

Store lyophilized material sealed at -20°C, protected from light and moisture. After reconstitution, store at 2–8°C short-term or aliquot and freeze at -20°C, avoiding repeated freeze-thaw cycles.

Do you provide dosing or usage instructions?

No. All products are supplied strictly for laboratory research use only. We do not provide dosing, administration, or usage guidance of any kind. Researchers determine experimental parameters according to their own validated protocols and applicable regulations.

Research Context

Provided for scientific background only; this does not describe any product use.

GPCR pharmacology — reference dual agonist in receptor-binding and cAMP-accumulation assays (e.g., HEK293 systems expressing GIPR/GLP-1R).
Receptor selectivity / biased-agonism studies — tool compound for probing balanced vs. biased engagement of GIPR relative to GLP-1R.
Incretin receptor signaling research — referenced in in-vitro/cellular models of dual-receptor signaling.
Analytical method development — lipidated-peptide reference in HPLC and MS method development.

Handling & Storage

For laboratory research handling only.

Reconstitution. Reconstitution solvent should be selected according to your experimental protocol and stability requirements; common research-grade options include HPLC-grade ultrapure water or dilute acetic acid. Validate compatibility with your assay system before use. Add solvent slowly down the vial wall; do not shake; allow to dissolve fully.

Storage — lyophilized. Sealed at -20°C, protected from light and moisture.

Storage — reconstituted. 2–8°C short-term, or aliquot and freeze -20°C. Avoid repeated freeze-thaw. Determine working concentrations using your own validated laboratory methods.

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