GLP-3RT
GLP-3RT is a research peptide designed to mimic glucagon-like peptide functions, with investigational roles in glucose metabolism and insulin regulation. It is provided in sterile lyophilized form, suitable for metabolic and endocrine laboratory research.
Price range: $85.00 through $280.00
| Quantity | Price | Discount |
|---|---|---|
| 5-10 | $81.60 | 4% |
| 11-15 | $78.20 | 8% |
| 16-20 | $74.80 | 12% |
| 21+ | $71.40 | 16% |
🧬 99%+ HPLC Purity
🧪 Every Batch 3rd-Party Tested
📄 Lot COA Before You Buy
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🇺🇸 USA Shipped
GLP-3RT is a synthetic 39-amino-acid peptide that acts as a triple agonist at three receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR). It is engineered from an incretin peptide backbone and incorporates non-coded residues (including α-aminoisobutyric acid, Aib) and a lipidated lysine side chain that contribute to its structural stability profile.
This product is supplied as a lyophilized powder, synthesized by solid-phase peptide synthesis (SPPS) and characterized by HPLC (purity) and LC-MS (identity). It is intended exclusively for in-vitro laboratory research and analytical applications.
In the research literature, GLP-3RT is referenced as a reference triple-receptor agonist and is used as a tool compound in the study of GLP-1R, GIPR, and GCGR receptor pharmacology and signaling.
| Size | 10mg, 15mg, 30mg, 60mg |
|---|---|
| Compound Name | GLP-3RT |
| Synonyms / Also Known As | GLP-3RT; LY3437943; LY-3437943 |
| CAS Number | 2381089-83-2 |
| Molecular Formula | C₂₂₁H₃₄₂N₄₆O₆₈ |
| Molecular Weight | ~4731.33 g/mol |
| Peptide Length | 39 amino acids (synthetic) |
| Structure | Synthetic peptide with C-terminal amide; contains non-coded residues (Aib) and a lipidated (fatty-diacid) Lys side chain |
| Receptor Targets | GLP-1R, GIPR, GCGR (triple agonist) |
| Compound Class | Synthetic incretin/glucagon triple-receptor agonist peptide |
| Purity | ≥99% (HPLC) |
| Identity Confirmation | Confirmed by LC-MS (per lot COA) |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water / aqueous buffer |
| Vial Contents | 10mg or 15mg or 30mg |
| Storage (lyophilized) | -20°C, sealed, protected from light/moisture |
| Storage (reconstituted) | 2–8°C short-term; aliquot & freeze -20°C for longer; avoid freeze-thaw cycles |
| Synthesis | Solid-phase peptide synthesis (SPPS) |
| Testing Lab | Freedom Diagnostics |
| Test Methods | Purity by HPLC; identity by LC-MS |
| Shipped From | USA |
| Certificate of Analysis | Lot-specific COA available |
GLP-3RT — Frequently Asked Questions
What is GLP-3RT?
GLP-3RT is a synthetic 39-amino-acid peptide that acts as a triple agonist at the GLP-1, GIP, and glucagon receptors. This product is supplied as a lyophilized powder for laboratory research use only.
What is the molecular weight and CAS number of GLP-3RT?
GLP-3RT has an approximate molecular weight of 4731.33 g/mol and CAS number 2381089-83-2. It is a 39-amino-acid synthetic peptide.
What receptors does GLP-3RT target?
In receptor-pharmacology research, GLP-3RT is characterized as a triple agonist at the GLP-1 receptor (GLP-1R), the GIP receptor (GIPR), and the glucagon receptor (GCGR).
What purity is this GLP-3RT?
This product is ≥99% pure as verified by HPLC, with identity confirmed by LC-MS. A lot-specific Certificate of Analysis from a third-party laboratory is available.
How should GLP-3RT be stored?
Store lyophilized material sealed at -20°C, protected from light and moisture. After reconstitution, store at 2–8°C for short-term use or aliquot and freeze at -20°C, avoiding repeated freeze-thaw cycles.
Is a Certificate of Analysis (COA) available?
Yes. Each lot has a Certificate of Analysis from an independent third-party laboratory documenting HPLC purity and LC-MS identity confirmation, tied to the vial lot number.
For laboratory research handling only.
Reconstitution. Reconstitution solvent should be selected according to your experimental protocol and stability requirements. Common research-grade options include HPLC-grade ultrapure water or dilute acetic acid; for assays requiring multi-day stability from a single vial, some laboratories select preservative-containing sterile water. Validate compatibility with your assay system before use. Add solvent slowly down the vial wall; do not shake vigorously, and allow to dissolve fully before use.
Storage — lyophilized. Store sealed at -20°C, protected from light and moisture.
Storage — reconstituted. Store at 2–8°C for short-term use, or aliquot and freeze at -20°C for longer-term storage. Avoid repeated freeze-thaw cycles. Determine working concentrations using your own validated laboratory methods.
The following describes investigative contexts in which this compound appears in the scientific literature. Provided for scientific background only; this does not describe any product use.
GPCR pharmacology — used as a reference triple agonist in receptor-binding and cAMP-accumulation assays (e.g., CRE-luc, HTRF cAMP) at GLP-1R, GIPR, and GCGR.
Receptor selectivity / potency-ratio studies — a tool compound for probing engineered potency ratios and crosstalk across the three receptor systems.
Incretin/glucagon receptor signaling research — referenced in in-vitro and cellular models of multi-receptor signaling integration.
Analytical method development — used as a lipidated-peptide reference in HPLC and MS method development.
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7 reviews for GLP-3RT
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10 stars
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