Thymosin Alpha-1 10mg
Thymosin Alpha-1 (also known as TA-1, TA1, Tα1, thymalfasin) is a synthetic 28-amino-acid N-terminally acetylated peptide corresponding to the sequence of the endogenous thymic peptide first characterized in the Goldstein laboratory (CAS 62304-98-7, MW ~3108.3 g/mol). Supplied as a ≥99% HPLC-tested lyophilized powder, 10 mg per vial, for in-vitro and laboratory research applications only. Research Use Only — not for human or veterinary use.
$65.00
| Quantity | Price | Discount |
|---|---|---|
| 5-10 | $62.40 | 4% |
| 11-15 | $59.80 | 8% |
| 16-20 | $57.20 | 12% |
| 21+ | $54.60 | 16% |
🧬 99%+ HPLC Purity
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Thymosin Alpha-1 — also referred to as TA-1, TA1, Tα1, and by the INN thymalfasin — is a synthetic 28-amino-acid N-terminally acetylated peptide corresponding to the amino-acid sequence of the endogenous thymic peptide first isolated and sequenced by the laboratory of Allan L. Goldstein (originally at Albert Einstein College of Medicine and later at George Washington University) from thymosin fraction 5. The peptide has an approximate molecular weight of 3108.3 g/mol and CAS number 62304-98-7.
This product is supplied as a lyophilized powder at 10 mg per vial, synthesized by solid-phase peptide synthesis (SPPS) and characterized by HPLC (purity) and LC-MS (identity). It is intended exclusively for in-vitro laboratory research and analytical applications.
In the research literature, Thymosin Alpha-1 is referenced as a synthetic peptide used as a tool compound in the study of Toll-like receptor pathways, particularly TLR9 and TLR2 signaling, and in comparative studies of thymic-derived peptides.
| Compound Name | Thymosin Alpha-1 |
|---|---|
| Synonyms / Also Known As | TA-1; TA1; Tα1; Thymalfasin (INN); Thymosin α1; Thymosin α-1 |
| CAS Number | 62304-98-7 |
| Molecular Formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular Weight | ~3108.3 g/mol |
| Peptide Length | 28 amino acids (synthetic) |
| Sequence (one-letter) | Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN |
| N-terminal Modification | Acetylation (N-acetyl) |
| Structure | Synthetic linear peptide; N-terminally acetylated; free C-terminus |
| Reported Signaling Interactions (identity, literature-referenced) | Toll-like receptor 9 (TLR9), Toll-like receptor 2 (TLR2) |
| Compound Class | Synthetic thymic-derived peptide referenced in immunomodulatory research |
| Purity | ≥99% (HPLC) |
| Identity Confirmation | Confirmed by LC-MS |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water / aqueous buffer |
| Available Sizes | 10 mg |
| Storage (lyophilized) | -20°C, sealed, protected from light/moisture |
| Storage (reconstituted) | 2–8°C short-term; aliquot & freeze -20°C; avoid freeze-thaw |
| Synthesis | Solid-phase peptide synthesis (SPPS) |
| Testing Lab | Freedom Diagnostics |
| Test Methods | Purity by HPLC; identity by LC-MS |
| Shipped From | USA |
| Certificate of Analysis | Lot-specific COA available |
The following describes investigative contexts in which this compound appears in the scientific literature. Provided for scientific background only; this does not describe any product use.
- Toll-like receptor pharmacology — used as a reference peptide in in-vitro binding, reporter, and NF-κB pathway assays involving TLR9 and TLR2 constructs.
- Dendritic cell and monocyte signaling research — referenced in cellular models examining innate-immune receptor signaling in myeloid cells.
- Thymic peptide comparative studies — used alongside other thymus-derived synthetic peptides (thymosin β4, thymopentin) in comparative in-vitro characterization work.
- Analytical method development — used as an N-acetylated 28-mer reference in HPLC and MS method development.
For laboratory research handling only.
Reconstitution. Reconstitution solvent should be selected according to your experimental protocol and stability requirements. Common research-grade options include HPLC-grade ultrapure water or dilute acetic acid. Validate compatibility with your assay system before use. Add solvent slowly down the vial wall; do not shake vigorously, and allow to dissolve fully before use.
Storage — lyophilized. Store sealed at -20°C, protected from light and moisture.
Storage — reconstituted. Store at 2–8°C short-term, or aliquot and freeze at -20°C for longer-term storage. Avoid repeated freeze-thaw cycles. Determine working concentrations using your own validated laboratory methods.
Thymosin Alpha-1 10mg — Frequently Asked Questions
What is Thymosin Alpha-1?
Thymosin Alpha-1 — also known as TA-1, TA1, Tα1, or by the INN thymalfasin — is a synthetic 28-amino-acid N-terminally acetylated peptide corresponding to the sequence of a thymic peptide first characterized in the laboratory of Allan L. Goldstein. It is supplied as a lyophilized powder for laboratory research use only.
Is Thymosin Alpha-1 a peptide?
Yes. Thymosin Alpha-1 is a synthetic 28-amino-acid linear peptide with an N-terminal acetyl group. It is referenced in the research literature as a tool compound in Toll-like receptor and thymic-peptide studies.
What is the molecular weight and CAS number of Thymosin Alpha-1?
Thymosin Alpha-1 has an approximate molecular weight of 3108.3 g/mol and CAS number 62304-98-7. The molecular formula is C129H215N33O55.
What is the amino acid sequence of Thymosin Alpha-1?
The 28-residue sequence of Thymosin Alpha-1 is Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, N-terminally acetylated.
What receptors does Thymosin Alpha-1 interact with in the research literature?
In published receptor-pharmacology research, Thymosin Alpha-1 is characterized as interacting with Toll-like receptor 9 (TLR9) and Toll-like receptor 2 (TLR2).
What sizes and purity are available?
This product is available as 10 mg per vial at greater than or equal to 99% HPLC purity, with identity confirmed by LC-MS. A lot-specific Certificate of Analysis from a third-party laboratory is available.
How should Thymosin Alpha-1 be stored?
Store lyophilized material sealed at -20C, protected from light and moisture. After reconstitution, store at 2-8C short-term or aliquot and freeze at -20C, avoiding repeated freeze-thaw cycles.
Is a Certificate of Analysis (COA) available?
Yes. Each lot has a Certificate of Analysis from an independent third-party laboratory documenting HPLC purity and LC-MS identity confirmation, tied to the vial lot number.
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