5-AMINO-1MQ – 50mg

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quinolinium-salt research compound characterized in the biochemistry literature as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Supplied as a ≥99% HPLC-UV purity lyophilized powder, 10 mg labeled size, with identity confirmed by LC-MS ([M]⁺ observed at m/z 159.000). Lot-specific Certificate of Analysis from Freedom Diagnostics (USA). Research Use Only — not for human or veterinary use.

$85.00

Quantity	Price	Discount
5-10	$81.60	4%
11-15	$78.20	8%
16-20	$74.80	12%
21+	$71.40	16%

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Description

5-Amino-1MQ — also written as 5-Amino 1MQ, and by its full chemical name 5-amino-1-methylquinolinium — is a small-molecule quinolinium-salt research compound. It consists of a methylquinolinium heteroaromatic cation bearing an amino substituent at the 5-position and a methyl group at the ring nitrogen, and is typically supplied as the iodide salt. The compound has a cation molecular weight of approximately 159.21 g/mol (matching the [M]⁺ ion observed at m/z 159.000 on the lot LC-MS confirmation) and, as the iodide salt, an approximate salt-form molecular weight of 286.11 g/mol.

This product is supplied as an orange lyophilized powder — the characteristic color arises from the extended aromatic chromophore of the methylquinolinium ring system. The lot referenced here (5AMI-015-TPL) has a documented purity of 99.77% by HPLC with UV detection, with identity confirmed by LC-MS. Labeled vial size is 10 mg; net content per vial per the COA is 11.28 mg. Third-party characterization was performed by Freedom Diagnostics (USA). The product is intended exclusively for in-vitro laboratory research and analytical applications.

In the biochemistry research literature, 5-Amino-1MQ is characterized as a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), a cytosolic methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl methionine (SAM) to nicotinamide.

Additional information

Compound Name	5-Amino-1MQ
Full Chemical Name	5-Amino-1-methylquinolinium
Synonyms / Also Known As	5-Amino 1MQ; 5-amino-1-methylquinolinium; 1-methyl-5-aminoquinolinium; 5A1MQ (informal)
CAS Number	6042-01-3
Molecular Formula (cation)	C₁₀H₁₁N₂⁺
Molecular Weight (cation)	~159.21 g/mol
Molecular Weight (iodide salt)	~286.11 g/mol
MS Confirmation on COA	[M]⁺ observed at m/z 159.000 (matches quinolinium cation)
Structure Type	Small-molecule quinolinium salt (methylated heteroaromatic cation)
Reported Enzyme Target (identity, literature-referenced)	Nicotinamide N-methyltransferase (NNMT)
Compound Class	Small-molecule NNMT inhibitor referenced in biochemistry research
Product Type	Small molecule (not a peptide)
Purity	99.77% (HPLC-UV)
Identity Confirmation	Confirmed by LC-MS
Appearance	Orange lyophilized powder
Solubility	Typically water-soluble as the iodide salt
Available Sizes	50mg
Net Content per Vial (COA)	11.28 mg
Storage (lyophilized)	-20°C, sealed, protected from light/moisture
Storage (reconstituted)	2–8°C short-term; aliquot & freeze -20°C; avoid freeze-thaw
Synthesis	Organic small-molecule synthesis
Testing Lab	Freedom Diagnostics, USA
Principal Chemist (on COA)	Alex Johnson
Test Methods	Purity by HPLC with UV detection; identity by LC-MS
Lot Number	5AMI-015-TPL
Accession Number (COA)	2605280466
Shipped From	USA
Certificate of Analysis	Lot-specific COA available

Research Context

The following describes investigative contexts in which this compound appears in the scientific literature. Provided for scientific background only; this does not describe any product use.

Enzyme inhibition biochemistry — used as a reference small-molecule inhibitor in in-vitro NNMT enzyme-kinetics assays.
Methyltransferase selectivity studies — used as a probe compound in in-vitro selectivity profiling across methyltransferase enzyme families.
Structure–activity relationship (SAR) work — appears as a reference scaffold in synthetic-chemistry SAR studies of methylquinolinium-class inhibitors.
Cell-based enzyme-activity assays — used as a tool compound in in-vitro cellular NNMT-activity readout assays.
Analytical method development — used as a reference small molecule in HPLC-UV and LC-MS method development.

Handling & Storage (Laboratory)

For laboratory research handling only.

Reconstitution. Reconstitution solvent should be selected according to your experimental protocol and stability requirements. As a quinolinium iodide salt, 5-Amino-1MQ is typically water-soluble; HPLC-grade ultrapure water or aqueous buffer is a common research-grade option. Validate compatibility with your assay system before use. Add solvent slowly down the vial wall; allow to dissolve fully before use. The orange color characteristic of the methylquinolinium chromophore will remain visible in solution.

Storage — lyophilized. Store sealed at -20°C, protected from light and moisture. Quinolinium salts are generally light-sensitive; strict light protection is recommended.

Storage — reconstituted. Store at 2–8°C short-term, or aliquot and freeze at -20°C for longer-term storage. Avoid repeated freeze-thaw cycles. Determine working concentrations using your own validated laboratory methods.

5-Amino-1MQ 10mg — Frequently Asked Questions

What is 5-Amino-1MQ?

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quinolinium-salt research compound characterized in the biochemistry literature as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is supplied as an orange lyophilized powder for laboratory research use only.

Is 5-Amino-1MQ a peptide?

No. 5-Amino-1MQ is a small-molecule quinolinium salt, not a peptide. It is a methylated heteroaromatic cation, typically supplied as the iodide salt, and is manufactured by organic small-molecule synthesis rather than solid-phase peptide synthesis.

What is the mechanism of 5-Amino-1MQ?

In the published biochemistry research literature, 5-Amino-1MQ is characterized as a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl methionine to nicotinamide.

What is the molecular weight and CAS number of 5-Amino-1MQ?

The 5-amino-1-methylquinolinium cation has an approximate molecular weight of 159.21 g/mol, matching the [M]+ ion observed at m/z 159.000 on the lot LC-MS confirmation. As the iodide salt, the approximate molecular weight is 286.11 g/mol. The CAS number for the iodide salt form is 6042-01-3; confirm salt form against the lot Certificate of Analysis.

Why is 5-Amino-1MQ orange?

The orange color of the lyophilized powder derives from the extended aromatic chromophore of the methylquinolinium ring system. This is a characteristic property of the compound class and will remain visible when the material is reconstituted in aqueous buffer.

What sizes and purity are available?

5-Amino-1MQ is available in multiple vial sizes; this SKU is 10 mg labeled with 11.28 mg net content per the lot COA. Purity is 99.77 percent by HPLC with UV detection, with identity confirmed by LC-MS. A lot-specific COA from Freedom Diagnostics (USA) is available.

How should 5-Amino-1MQ be stored?

Store lyophilized material sealed at -20C, protected from light and moisture. Quinolinium salts are generally light-sensitive; strict light protection is recommended. After reconstitution, store at 2-8C short-term or aliquot and freeze at -20C, avoiding repeated freeze-thaw cycles.

Is a Certificate of Analysis (COA) available?

Yes. Each lot has a Certificate of Analysis from an independent third-party laboratory (Freedom Diagnostics, USA) documenting HPLC purity and LC-MS identity confirmation, tied to the vial lot number. The reference lot for this product line is 5AMI-015-TPL.

Do you provide dosing or usage instructions for 5-Amino-1MQ?

No. All products are supplied strictly for laboratory research use only. We do not provide dosing, administration, oral or sublingual or injection-route guidance, protocols, or usage calculators of any kind. Researchers determine experimental parameters according to their own validated protocols and applicable regulations.

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