MOTS-C 10mg
MOTS-c is a synthetic 16-amino-acid peptide corresponding to a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S ribosomal RNA gene, first characterized in the laboratory of Pinchas Cohen at the USC Leonard Davis School of Gerontology (CAS 1627580-64-6, MW ~2174.5 g/mol). Supplied as a ≥99% HPLC-UV purity lyophilized powder, 10 mg labeled size, with identity confirmed by LC-MS across four convergent charge states ([M+2H]²⁺, [M+3H]³⁺, [M+4H]⁴⁺, [M+5H]⁵⁺). Lot-specific Certificate of Analysis from Freedom Diagnostics (USA). Research Use Only — not for human or veterinary use.
Price range: $36.00 through $108.00
| Quantity | Price | Discount |
|---|---|---|
| 5-10 | $34.56 | 4% |
| 11-15 | $33.12 | 8% |
| 16-20 | $31.68 | 12% |
| 21+ | $30.24 | 16% |
🧬 99%+ HPLC Purity
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MOTS-c — full name “Mitochondrial Open reading frame of the Twelve S rRNA – c” — is a synthetic 16-amino-acid peptide corresponding to a mitochondrial-derived peptide (MDP) that is encoded within a short open reading frame in the human mitochondrial 12S ribosomal RNA gene. MDPs are peptides whose coding sequences are found within mitochondrial DNA rather than in nuclear DNA, and MOTS-c is among the earliest such peptides to be characterized. The peptide was first identified and characterized in the laboratory of Pinchas Cohen at the USC Leonard Davis School of Gerontology.
The peptide has a molecular weight of approximately 2174.5 g/mol and CAS number 1627580-64-6, with the one-letter sequence MRWQEMGYIFYPRKLR. On the lot referenced here (MOTS-210-TPL), identity is confirmed by LC-MS through convergent observation across four charge states — [M+5H]⁵⁺ at m/z 435.900, [M+4H]⁴⁺ at 544.600, [M+3H]³⁺ at 725.700, and [M+2H]²⁺ at 1088.500 — each back-calculating to the expected ~2174.5 Da mass. Documented purity by HPLC with UV detection is 99.45%. Third-party characterization was performed by Freedom Diagnostics (USA).
This product is supplied as a white lyophilized powder at 10 mg labeled size (11.14 mg net content per vial per the COA), synthesized by solid-phase peptide synthesis (SPPS). It is intended exclusively for in-vitro laboratory research and analytical applications.
In the research literature, MOTS-c is referenced as a synthetic mitochondrial-derived peptide used as a reference compound in biochemistry research on the MDP class.
| Size | 10mg, 40mg |
|---|---|
| Compound Name | MOTS-c |
| Full Name | Mitochondrial Open reading frame of the Twelve S rRNA – c |
| Synonyms / Also Known As | MOTSc; MOTS c; Mitochondrial-derived peptide MOTS-c; 12S rRNA-encoded MDP |
| CAS Number | 1627580-64-6 |
| Molecular Formula | C₁₀₀H₁₄₆N₃₀O₂₂S₂ |
| Molecular Weight | ~2174.5 g/mol |
| Peptide Length | 16 amino acids |
| Sequence (one-letter) | MRWQEMGYIFYPRKLR |
| Sequence (three-letter) | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| MS Confirmation on COA | Convergent identity confirmation across 4 charge states — [M+5H]⁵⁺ observed at m/z 435.900, [M+4H]⁴⁺ at 544.600, [M+3H]³⁺ at 725.700, [M+2H]²⁺ at 1088.500 (all back-calculating to ~2174.5 Da) |
| Origin (identity fact) | Encoded within the human mitochondrial 12S ribosomal RNA gene; one of the earliest characterized mitochondrial-derived peptides (MDPs) |
| Compound Class | Synthetic mitochondrial-derived peptide (MDP) referenced in biochemistry research |
| Product Type | Peptide |
| Purity | 99.45% (HPLC-UV) — per COA lot MOTS-210-TPL |
| Identity Confirmation | Confirmed by LC-MS (per lot COA) |
| Appearance | White lyophilized powder |
| Solubility | Water-soluble |
| Available Sizes | 10mg or 40mg |
| Net Content per Vial (COA) | 11.14 mg or 44.56 mg |
| Storage (lyophilized) | -20°C, sealed, protected from light/moisture |
| Storage (reconstituted) | 2–8°C short-term; aliquot & freeze -20°C; avoid freeze-thaw |
| Synthesis | Solid-phase peptide synthesis (SPPS) |
| Testing Lab | Freedom Diagnostics, USA |
| Principal Chemist (on COA) | Alex Johnson |
| Test Methods | Purity by HPLC with UV detection; identity by LC-MS |
| Lot Number | MOTS-210-TPL |
| Accession Number (COA) | 2605280457 |
| Shipped From | USA |
| Certificate of Analysis | Lot-specific COA available |
The following describes investigative contexts in which this compound appears in the scientific literature. Provided for scientific background only; this does not describe any product use.
- Mitochondrial-derived peptide (MDP) biochemistry — used as a reference peptide in in-vitro characterization of MDP biology alongside other mitochondrial-encoded peptides.
- Peptide biochemistry and structural studies — appears as a reference sequence in in-vitro peptide-characterization and structural biophysics work.
- Cellular assay development — used as a tool compound in in-vitro cellular MDP-response assays.
- Analytical method development — used as a reference peptide with a distinctive multi-charge-state MS profile in HPLC-UV and LC-MS method development.
For laboratory research handling only.
Reconstitution. Reconstitution solvent should be selected according to your experimental protocol and stability requirements. Common research-grade options include HPLC-grade ultrapure water or dilute acetic acid. Validate compatibility with your assay system before use. Add solvent slowly down the vial wall; do not shake vigorously, and allow to dissolve fully before use.
Storage — lyophilized. Store sealed at -20°C, protected from light and moisture.
Storage — reconstituted. Store at 2–8°C short-term, or aliquot and freeze at -20°C for longer-term storage. Avoid repeated freeze-thaw cycles. Determine working concentrations using your own validated laboratory methods.
MOTS-c 10mg — Frequently Asked Questions
What is MOTS-c?
MOTS-c is a synthetic 16-amino-acid peptide corresponding to a mitochondrial-derived peptide (MDP) that is encoded within a short open reading frame in the human mitochondrial 12S ribosomal RNA gene. It was first characterized in the laboratory of Pinchas Cohen at the USC Leonard Davis School of Gerontology and is supplied as a lyophilized powder for laboratory research use only.
What does MOTS-c stand for?
MOTS-c stands for "Mitochondrial Open reading frame of the Twelve S rRNA - c." The name reflects the peptide's encoded origin within a small open reading frame in the mitochondrial 12S ribosomal RNA gene.
Is MOTS-c a peptide?
Yes. MOTS-c is a synthetic 16-amino-acid peptide, referenced in the research literature as a mitochondrial-derived peptide (MDP). It is manufactured by solid-phase peptide synthesis.
What is the amino acid sequence of MOTS-c?
The 16-residue sequence of MOTS-c is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, or in one-letter code MRWQEMGYIFYPRKLR.
What is the molecular weight and CAS number of MOTS-c?
MOTS-c has a molecular formula of C100H146N30O22S2 and an approximate molecular weight of 2174.5 g/mol. The CAS number is 1627580-64-6. Identity on the lot COA is confirmed by LC-MS across four charge states — [M+5H]5+ at 435.900, [M+4H]4+ at 544.600, [M+3H]3+ at 725.700, and [M+2H]2+ at 1088.500 — all back-calculating to the expected mass.
What sizes and purity are available?
MOTS-c is available as 10 mg per vial (11.14 mg net content per the lot COA). Purity is 99.45 percent by HPLC with UV detection, with identity confirmed by LC-MS. A lot-specific COA from Freedom Diagnostics (USA) is available.
How should MOTS-c be stored?
Store lyophilized material sealed at -20C, protected from light and moisture. After reconstitution, store at 2-8C short-term or aliquot and freeze at -20C, avoiding repeated freeze-thaw cycles.
Is a Certificate of Analysis (COA) available?
Yes. Each lot has a Certificate of Analysis from an independent third-party laboratory (Freedom Diagnostics, USA) documenting HPLC purity and LC-MS identity confirmation, tied to the vial lot number. The reference lot for this product line is MOTS-210-TPL.
Do you provide dosing or usage instructions for MOTS-c?
No. All products are supplied strictly for laboratory research use only. We do not provide dosing, administration, or usage guidance of any kind. Researchers determine experimental parameters according to their own validated protocols and applicable regulations.
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